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DC Field | Value | Language |
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dc.contributor.author | Kumar, Mukesh | en_US |
dc.contributor.author | Ojha, Srikant | en_US |
dc.contributor.author | Rai, Priyanka | en_US |
dc.contributor.author | JOSHI, ALAUMY | en_US |
dc.contributor.author | KAMAT, SIDDHESH S. | en_US |
dc.contributor.author | Roop Mallik | en_US |
dc.date.accessioned | 2019-10-23T08:48:20Z | |
dc.date.available | 2019-10-23T08:48:20Z | |
dc.date.issued | 2019-10 | en_US |
dc.identifier.citation | Journal of Cell Biology, 218(11), 3697-3713. | en_US |
dc.identifier.issn | 0021-9525 | en_US |
dc.identifier.issn | 1540-8140 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4152 | - |
dc.identifier.uri | https://doi.org/10.1083/jcb.201903102 | en_US |
dc.description.abstract | Triglyceride-rich lipid droplets (LDs) are catabolized with high efficiency in hepatocytes to supply fatty acids for producing lipoprotein particles. Fasting causes a massive influx of adipose-derived fatty acids into the liver. The liver in the fasted state is therefore bloated with LDs but, remarkably, still continues to secrete triglycerides at a constant rate. Here we show that insulin signaling elevates phosphatidic acid (PA) dramatically on LDs in the fed state. PA then signals to recruit kinesin-1 motors, which transport LDs to the peripherally located smooth ER inside hepatocytes, where LDs are catabolized to produce lipoproteins. This pathway is down-regulated homeostatically when fasting causes insulin levels to drop, thus preventing dangerous elevation of triglycerides in the blood. Further, we show that a specific peptide against kinesin-1 blocks triglyceride secretion without any apparent deleterious effects on cells. Our work therefore reveals fundamental mechanisms that maintain lipid homeostasis across metabolic states and leverages this knowledge to propose a molecular target against hyperlipidemia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.subject | Insulin activates | en_US |
dc.subject | intracellular transport | en_US |
dc.subject | lipid droplets | en_US |
dc.subject | Release triglycerides liver | en_US |
dc.subject | TOC-OCT-2019 | en_US |
dc.subject | 2019 | en_US |
dc.title | Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Biology | en_US |
dc.identifier.sourcetitle | Journal of Cell Biology | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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