Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4221
Title: | Impact of substituent effects on the design of beta-sheet mimetics and beta-double helices from (E)-vinylogous gamma-amino acid oligomers |
Authors: | VEERESH, KURUVA SINGH, MANJEET GOPI, HOSAHUDYA N. Dept. of Chemistry |
Keywords: | O Hydrogen-Bond Peptide Helices Hybrid Peptides Lipid Bilayer Gramicidin-A Antiparallel Conformation Recognition Channel Residue TOC-NOV-2019 2019 |
Issue Date: | Nov-2019 |
Publisher: | Royal Society of Chemistry |
Citation: | Organic & Biomolecular Chemistry, 17(41), 9226-9231. |
Abstract: | Here we report the design, single crystal conformations, impact of the substituents and structural differences of two structurally important motifs, beta-sheets and beta-double helices. Though beta-sheets are common structural motifs in protein structures, beta-double helices are not common in proteins and peptides. We found that both beta-sheet mimetics and beta-double helices can be constructed from the homooligomers of alpha,beta-unsaturated gamma-amino acids. Results suggested that introducing gem-dialkyl substitutions at the gamma-carbon of the homooligomer of alpha,beta-unsaturated gamma-amino acids resulted in the beta-double helix conformation, while the same oligomer with monosubstitution at the gamma-carbon displayed a beta-sheet structure. |
URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4221 https://doi.org/10.1039/c9ob01801h |
ISSN: | 1477-0520 1477-0539 |
Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.