Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4576
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dc.contributor.authorSARKAR, SUSOVANen_US
dc.contributor.authorDAGAR, SHIKHAen_US
dc.contributor.authorVERMA, AJAYen_US
dc.contributor.authorRAJAMANI, SUDHAen_US
dc.date.accessioned2020-04-30T06:03:03Z
dc.date.available2020-04-30T06:03:03Z
dc.date.issued2020-03en_US
dc.identifier.citationScientific Reports, 10.en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4576-
dc.identifier.urihttps://doi.org/10.1038/s41598-020-61372-wen_US
dc.description.abstractProtocellular membranes are thought to be composed of mixtures of single chain amphiphiles, such as fatty acids and their derivatives, moieties that would have been part of the complex prebiotic chemical landscape. The composition and physico-chemical properties of these prebiological membranes would have been significantly affected and regulated by their environment. In this study, pertinent properties were systematically characterized, under early Earth conditions. Two different fatty acids were mixed with their respective alcohol and/or glycerol monoester derivatives to generate combinations of binary and tertiary membrane systems. Their properties were then evaluated as a function of multiple factors including their stability under varying pH, varying Mg2+ ion concentrations, dilution regimes, and their permeability to calcein. Our results demonstrate how environmental constraints would have acted as important prebiotic selection pressures to shape the evolution of prebiological membranes. The study also illustrates that compositionally diverse membrane systems are more stable and robust to multiple selection pressures, thereby making them more suitable for supporting protocellular life.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectBiochemistryen_US
dc.subjectChemical biologyen_US
dc.subjectLipidsen_US
dc.subjectMembranesen_US
dc.subjectMolecular evolutionen_US
dc.subjectChemical origin of lifeen_US
dc.subjectTOC-APR-2020en_US
dc.subject2020en_US
dc.subject2020-APR-WEEK5en_US
dc.titleCompositional heterogeneity confers selective advantage to model protocellular membranes during the origins of cellular lifeen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleScientific Reportsen_US
dc.publication.originofpublisherForeignen_US
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