Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4609

Title:	Continuous-Flow Accelerated Sulfation of Heparan Sulfate Intermediates
Authors:	ANAND, SAURABH MARDHEKAR, SANDHYA RAIGAWALI, RAKESH MOHANTA, NIRMALA JAIN, PRASHANT SHANTHAMURTHY, CHETHAN D. GNANAPRAKASAM, BOOPATHY KIKKERI, RAGHAVENDRA Dept. of Chemistry
Keywords:	Binding Oligosaccharides Activation TOC-MAY-2020 2020 2020-MAY-WEEK3
Issue Date:	Apr-2020
Publisher:	American Chemical Society
Citation:	Organic Letters, 22(9), 3402-3406.
Abstract:	We report for the first time a continuous-flow strategy to execute O-sulfation modification of heparan sulfate (HS) oligosaccharides. A systematic investigation of the influence of the flow parameters on the installation of the sulfate group on glucosamine monosaccharide can aid the development of a comprehensive, quick, and reliable strategy for O-sulfation of HS oligosaccharide precursors. Deprotection of the sulfated heparin intermediates led to the development of a comprehensive biologically inspired oligosaccharide library to understand the crucial structure–function relationship of HS.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4609 https://doi.org/10.1021/acs.orglett.0c00878
ISSN:	1523-7060 1523-7052
Appears in Collections:	JOURNAL ARTICLES

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