Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4898
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMOHANTA, NIRMALAen_US
dc.contributor.authorNAIR, KRISHNAen_US
dc.contributor.authorSUTAR, DASHARATH VISHAMBARen_US
dc.contributor.authorGNANAPRAKASAM, BOOPATHYen_US
dc.date.accessioned2020-07-24T05:59:05Z
dc.date.available2020-07-24T05:59:05Z
dc.date.issued2020-08en_US
dc.identifier.citationReaction Chemistry & Engineering, 5(8), 1501-1508.en_US
dc.identifier.issn2058-9883en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4898-
dc.identifier.urihttps://doi.org/10.1039/D0RE00171Fen_US
dc.description.abstractContinuous-flow chemistry is a modern technology that encompasses the green chemistry principles for the multi-gram synthesis of various API and drugs. Herein, we have developed a highly efficient and environmentally benign metal-free alkylation of 1,3-dicarbonyl compounds using secondary alcohols in the presence of inexpensive Amberlyst®-15 under continuous-flow. This method has a broad substrate scope with a variety of secondary alcohols and water as a byproduct. The Amberlyst®-15 is recyclable and reusable for the alkylation reaction under batch/continuous-flow technology. Furthermore, a continuous-flow technology driven Mannich reaction was demonstrated under an acid-free condition. In addition, a continuous-flow Fischer indole strategy for the ondansetron with an improved yield was demonstrated. Additionally, all these reactions were demonstrated with multi-gram scale synthesis without lowering the yield under batch/continuous-flow technology.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectChemistryen_US
dc.subjectTOC-JUL-2020en_US
dc.subject2020en_US
dc.subject2020-JUL-WEEK4en_US
dc.titleA continuous-flow approach for the multi-gram scale synthesis of C2-alkyl- or β-amino functionalized 1,3-dicarbonyl derivatives and ondansetron drug using 1,3-dicarbonylsen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleReaction Chemistry & Engineeringen_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.