Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4906
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAwathale, Sanjay N.en_US
dc.contributor.authorDudhbhate, Biru B.en_US
dc.contributor.authorRahangdale, Rakesh R.en_US
dc.contributor.authorBorkar, Chandrashekhar D.en_US
dc.contributor.authorSUBHEDAR, NISHIKANT K.en_US
dc.contributor.authorKokare, Dadasaheb M.en_US
dc.date.accessioned2020-07-24T05:59:05Z
dc.date.available2020-07-24T05:59:05Z
dc.date.issued2020-07en_US
dc.identifier.citationJournal of Neuroscience Methods, 341.en_US
dc.identifier.issn0165-0270en_US
dc.identifier.issn1872-678Xen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4906-
dc.identifier.urihttps://doi.org/10.1016/j.jneumeth.2020.108791en_US
dc.description.abstractBackground Anger is one of the primary emotions that profoundly impacts our daily life. Although the neural basis of anger needs to be explored on high priority, the field has not sufficiently advanced, perhaps due to the lack of a suitable animal model. New method We fabricated arenas in which the hungry rat can see and smell food but can not consume it. These animals seemed hyperactive and we monitored the (a) motor activity to access food, (b) biting behaviour, (c) blood pressure, heart rate and nor-epinephrine (NE) in plasma, (d) 5-HT and its metabolite in CSF, (e) effect of diazepam, 5-HT agonist, and antagonist on the behaviour, and (f) expression of immediate early gene in discrete areas of the brain. Results The fasted animal frantically tries to acquire food. It engages in intense biting of the separator plate; the behaviour was considered as an expression of anger-like emotion. These behaviours were attenuated following pre-treatment with diazepam, fluoxetine (both ip) or 5-HT1A receptor agonist (icv), but potentiated by 5-HT1A antagonist (icv). Concomitantly, an increase in the blood pressure, heart rate and NE in plasma, but a decrease in 5-HT and 5-HIAA in the CSF was noted. The animals showed activation of neuronal c-Fos in different brain areas compared to fasted or refed controls. Comparison with existing methods A novel animal paradigm for assessment of anger. Conclusions The protocol enables us to generate and evaluate anger-like responses in rat and permits insights into the neurological basis of anger.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectAngeren_US
dc.subjectTOC-JUL-2020en_US
dc.subject2020en_US
dc.subject2020-JUL-WEEK4en_US
dc.titleDenial of food to the hungry rat: A novel paradigm for induction and evaluation of anger-like emotionen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleJournal of Neuroscience Methodsen_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.