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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4923| Title: | Structural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexes |
| Authors: | GUPTA, MANOJ KUMAR Madhanagopal, Bharath Raj DATTA, DHRUBAJYOTI GANESH, KRISHNA N. Dept. of Chemistry |
| Keywords: | Peptide nucleic-acids Strand displacement Sequence Analogs Thermodynamics Recognition Cytosine Thymine Dna/Rna Future TOC-JUL-2020 2020 2020-JUL-WEEK5 |
| Issue Date: | Jul-2020 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 22(13), 5255-5260. |
| Abstract: | Bimodal PNAs are new PNA constructs designed to bind two different cDNA sequences synchronously to form double duplexes. They are synthesized on solid phase using sequential coupling and click reaction to introduce a second base in each monomer at Cα via alkyltriazole linker. The ternary bimodal PNA:DNA complexes show stability higher than that of individual duplexes. Bimodal PNAs are appropriate to create higher-order fused nucleic acid assemblies. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4923 https://doi.org/10.1021/acs.orglett.0c01950 |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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