Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5048
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dc.contributor.authorHEGDE, SUSHMITHAen_US
dc.contributor.authorSOORY, AMARENDRANATHen_US
dc.contributor.authorKADUSKAR, BHAGYASHREEen_US
dc.contributor.authorRATNAPARKHI, GIRISH S.en_US
dc.date.accessioned2020-09-19T15:00:06Z-
dc.date.available2020-09-19T15:00:06Z-
dc.date.issued2020-08en_US
dc.identifier.citationFly.en_US
dc.identifier.issn1933-6934en_US
dc.identifier.issn1933-6942en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5048-
dc.identifier.urihttps://doi.org/10.1080/19336934.2020.1808402en_US
dc.description.abstractPost-translational modifications (PTMs) are critical drivers and attenuators for proteins that regulate immune signalling cascades in host defence. In this review, we explore functional roles for one such PTM, the small ubiquitin-like modifier (SUMO). Very few of the SUMO conjugation targets identified by proteomic studies have been validated in terms of their roles in host defence. Here, we compare and contrast potential SUMO substrate proteins in immune signalling for flies and mammals, with an emphasis on NFκB pathways. We discuss, using the few mechanistic studies that exist for validated targets, the effect of SUMO conjugation on signalling and also explore current molecular models that explain regulation by SUMO. We also discuss in detail roles of evolutionary conservation of mechanisms, SUMO interaction motifs, crosstalk of SUMO with other PTMs, emerging concepts such as group SUMOylation and finally, the potentially transforming roles for genome-editing technologies in studying the effect of PTMs.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectImmunityen_US
dc.subjectPtmen_US
dc.subjectSignal transductionen_US
dc.subjectSimen_US
dc.subjectUbiquitinen_US
dc.subjectTranscriptional activation/repressionen_US
dc.subjectCrosstalken_US
dc.subjectCRISPRen_US
dc.subjectnfκben_US
dc.subject2020en_US
dc.subject2020-SEP-WEEK3en_US
dc.subjectTOC-SEP-2020en_US
dc.titleSUMO conjugation regulates immune signallingen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleFly.en_US
dc.publication.originofpublisherForeignen_US
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