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Title: Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties
Authors: Vysabhattar, Raman
Dept. of Chemistry
Keywords: PNA
Cyanuryl PNA
Issue Date: Feb-2008
Publisher: Elsevier B.V.
Citation: Tetrahedron Letters, 49(8), 1314-1318.
Abstract: The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N′-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer.
ISSN: 0040-4039
Appears in Collections:JOURNAL ARTICLES

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