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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5124| Title: | Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties |
| Authors: | Vysabhattar, Raman GANESH, KRISHNA N. Dept. of Chemistry |
| Keywords: | PNA Cyanuryl PNA 2008 |
| Issue Date: | Feb-2008 |
| Publisher: | Elsevier B.V. |
| Citation: | Tetrahedron Letters, 49(8), 1314-1318. |
| Abstract: | The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N′-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5124 https://doi.org/10.1016/j.tetlet.2007.12.095 |
| ISSN: | 0040-4039 |
| Appears in Collections: | JOURNAL ARTICLES |
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