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Title: Capturing a novel metastable polymorph of the anticancer drug gefitinib
Authors: Thorat, Shridhar H.
Patwadkar, Manjusha V.
Gonnade, Rajesh G.
Dept. of Chemistry
Keywords: Chemistry
Issue Date: Oct-2014
Publisher: Royal Society of Chemistry
Citation: Crystengcomm, 16(37), 8638-8641.
Abstract: Gefitinib, a life-extending anticancer drug, exhibits solvent-mediated conformational polymorphism to yield stable (form I) and novel metastable (form II) polymorphs. Crystal structure analysis revealed 3D isostructurality in the molecular organization of the polymorphs, and the metastable polymorph undergoes a crystal-to-crystal thermal phase transition to the stable polymorph.
ISSN: 1466-8033
Appears in Collections:JOURNAL ARTICLES

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