Cγ-Aminopropylene peptide nucleic acid (amp-PNA): chiral cationic PNAs with superior PNA:DNA/RNA duplex stability and cellular uptake

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5281

Title:	Cγ-Aminopropylene peptide nucleic acid (amp-PNA): chiral cationic PNAs with superior PNA:DNA/RNA duplex stability and cellular uptake
Authors:	KUMAR, PRAMOD JAIN, DEEPAK R. Dept. of Biology
Keywords:	Cationic PNA Spacer chain DNA/RNA hybridization Cell penetration 2015
Issue Date:	May-2015
Publisher:	Elsevier B.V.
Citation:	Tetrahedron, 71(21), 3378-3384.
Abstract:	Inherently cationic and chiral Cγ-aminopropylene peptide nucleic acid (amp-PNA) have been synthesized with three carbon spacer chain from the backbone. The modified amp-PNAs have shown to stabilize (ΔTm) the PNA:DNA duplexes better than that of corresponding PNA:RNA duplexes. However, the PNA:RNA duplexes have higher thermal stability (Tm) compared to PNA:DNA duplexes for both modified and unmodified PNAs. The live cell imaging of amp-PNAs demonstrated their effective penetration inside the MCF-7 cells and found to be accumulated in the vicinity of the nuclear membrane in the cytoplasm.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5281 https://doi.org/10.1016/j.tet.2015.03.093
ISSN:	0040-4020
Appears in Collections:	JOURNAL ARTICLES

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