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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | KUMAR, PRAMOD | en_US |
| dc.contributor.author | JAIN, DEEPAK R. | en_US |
| dc.date.accessioned | 2020-10-26T06:38:21Z | - |
| dc.date.available | 2020-10-26T06:38:21Z | - |
| dc.date.issued | 2015-05 | en_US |
| dc.identifier.citation | Tetrahedron, 71(21), 3378-3384. | en_US |
| dc.identifier.issn | 0040-4020 | en_US |
| dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5281 | - |
| dc.identifier.uri | https://doi.org/10.1016/j.tet.2015.03.093 | en_US |
| dc.description.abstract | Inherently cationic and chiral Cγ-aminopropylene peptide nucleic acid (amp-PNA) have been synthesized with three carbon spacer chain from the backbone. The modified amp-PNAs have shown to stabilize (ΔTm) the PNA:DNA duplexes better than that of corresponding PNA:RNA duplexes. However, the PNA:RNA duplexes have higher thermal stability (Tm) compared to PNA:DNA duplexes for both modified and unmodified PNAs. The live cell imaging of amp-PNAs demonstrated their effective penetration inside the MCF-7 cells and found to be accumulated in the vicinity of the nuclear membrane in the cytoplasm. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier B.V. | en_US |
| dc.subject | Cationic PNA | en_US |
| dc.subject | Spacer chain | en_US |
| dc.subject | DNA/RNA hybridization | en_US |
| dc.subject | Cell penetration | en_US |
| dc.subject | 2015 | en_US |
| dc.title | Cγ-Aminopropylene peptide nucleic acid (amp-PNA): chiral cationic PNAs with superior PNA:DNA/RNA duplex stability and cellular uptake | en_US |
| dc.type | Article | en_US |
| dc.contributor.department | Dept. of Biology | en_US |
| dc.identifier.sourcetitle | Tetrahedron | en_US |
| dc.publication.originofpublisher | Foreign | en_US |
| Appears in Collections: | JOURNAL ARTICLES | |
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