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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5322| Title: | Supramolecular metalloglycodendrimers selectively modulate lectin binding and delivery of Ru(II) complexes into mammalian cells |
| Authors: | BAVIREDDI, HARIKRISHNA MURTHY, RAGHAVENDRA VASUDEVA GADE, MADHURI SANGABATHUNI, SIVAKOTI KIKKERI, RAGHAVENDRA Dept. of Chemistry |
| Keywords: | Endoplasmic-Reticulum Stress Capped Quantum Dots Ruthenium Complexes Anticancer Agents Cancer-Cells Subcellular-Localization Cellular Uptake DNA Apoptosis Reveals 2016 |
| Issue Date: | Dec-2016 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Organic & Biomolecular Chemistry, 14(46), 10816-10821. |
| Abstract: | A host–guest interaction between Ru(II)-complexes and sugar-capped β-cyclodextrin was employed to synthesize metalloglycodendrimers. These glycodendrimers demonstrated selective carbohydrate–protein interactions and controlled the delivery of the Ru(II) complexes into cancer cells, which may facilitate cell-specific apoptosis. Lectin binding assay revealed micromolar range IC50 values with different plant lectins. Cell viability assay and confocal imaging studies of Ru(II) complexes exhibited cytotoxic activities in cancer cells compared to normal cells with IC50 values close to other literature Ru(II) complexes. The cell death inducer was found to accumulate favorably to the endoplasmic reticulum (ER) and induced ER stress in cells. The upregulation of CHOP, caspase-3 and caspase-12 disturbed the ER morphology initiating the apoptosis pathway. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5322 https://doi.org/10.1039/C6OB01546H |
| ISSN: | 1477-0520 1477-0539 |
| Appears in Collections: | JOURNAL ARTICLES |
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