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DC Field | Value | Language |
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dc.contributor.author | HARNE, SHRIKANT | en_US |
dc.contributor.author | PANANGHAT, GAYATHRI | en_US |
dc.contributor.author | Béven, Laure | en_US |
dc.date.accessioned | 2020-10-29T05:34:01Z | |
dc.date.available | 2020-10-29T05:34:01Z | |
dc.date.issued | 2020-10 | en_US |
dc.identifier.citation | Frontiers in Microbiology, 11. | en_US |
dc.identifier.issn | 1664-302X | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5326 | |
dc.identifier.uri | https://doi.org/10.3389/fmicb.2020.589279 | en_US |
dc.description.abstract | Spiroplasmas are cell-wall-deficient helical bacteria belonging to the class Mollicutes. Their ability to maintain a helical shape in the absence of cell wall and their motility in the absence of external appendages have attracted attention from the scientific community for a long time. In this review we compare and contrast motility, shape determination and cytokinesis mechanisms of Spiroplasma with those of other Mollicutes and cell-walled bacteria. The current models for rod-shape determination and cytokinesis in cell-walled bacteria propose a prominent role for the cell wall synthesis machinery. These models also involve the cooperation of the actin-like protein MreB and FtsZ, the bacterial homolog of tubulin. However the exact role of the cytoskeletal proteins is still under much debate. Spiroplasma possess MreBs, exhibit a rod-shape dependent helical morphology, and divide by an FtsZ-dependent mechanism. Hence, spiroplasmas represent model organisms for deciphering the roles of MreBs and FtsZ in fundamental mechanisms of non-spherical shape determination and cytokinesis in bacteria, in the absence of a cell wall. Identification of components implicated in these processes and deciphering their functions would require genetic experiments. Challenges in genetic manipulations in spiroplasmas are a major bottleneck in understanding their biology. We discuss advancements in genome sequencing, gene editing technologies, super-resolution microscopy and electron cryomicroscopy and tomography, which can be employed for addressing long-standing questions related to Spiroplasma biology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media S.A. | en_US |
dc.subject | Spiroplasma Biology | en_US |
dc.subject | 2020 | en_US |
dc.subject | 2020-OCT-WEEK4 | en_US |
dc.subject | TOC-OCT-2020 | en_US |
dc.title | Exploring Spiroplasma Biology: Opportunities and Challenges | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Biology | en_US |
dc.identifier.sourcetitle | Frontiers in Microbiology | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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