Thiol mediated/activated prodrugs of sulfur dioxide (SO2) having anti-bacterial activity

Abstract

Disclosed herein are thiol mediated/activated prodrugs of SO2, particularly 2, 4-dinitrophenylsulfonamide analogs, having Formula-I or pharmaceutically acceptable salts thereof exhibiting tunable release profiles of SO2 with significant therapeutic efficacy against bacterial infections. Further, the present invention provides pharmaceutical compositions comprising compound of Formula I or pharmaceutically acceptable salts thereof, along with pharmaceutically acceptable carriers/excipients.