Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5667
Title: Silver assisted stereo-directed assembly of branched peptide nucleic acids into four-point nanostars
Authors: Madhanagopal, Bharath Raj
Kumar, Jatish
GANESH, KRISHNA N.
Dept. of Chemistry
Keywords: Collagen Peptides
Crystal-Structure
DNA
PNA
Analogs
Chirality
2020
Issue Date: Nov-2020
Publisher: Royal Society of Chemistry
Citation: Nanoscale, 12(42), 21665-21673.
Abstract: Branched chiral peptide nucleic acids br(4S/R)-PNA with three arms of PNA-C4 strands were constructed on a central chiral core of 4(R/S)-aminoproline as the branching center. The addition of Ag+ triggered the self-assembly of branched PNAs through the formation of C–Ag+–C metallo base pairing of the three PNA C4 arms leading to non-covalent dendrimers, whose architecture is directed by the C4(R/S)-stereocenter of core 4-aminoproline. The 4S-aminoprolyl core enabled the precise formation of four-pointed nanostars that was not realised with 4R-aminoprolyl or acyclic, achiral aminoethyl glycyl PNA cores. The dendritic assembly of 4 pointed nanostars exhibited net chirality of base stacks in CD spectra, while the base stack assembly from br(4R)-PNA 2 was overall achiral. The results demonstrate that the silver assisted, 4S-aminoproline core stereo selective chiral assembly of branched PNAs manifests into nanostar morphology. The chiral branched PNAs open new vistas in the supramolecular organization of nucleic acids.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5667
https://doi.org/10.1039/D0NR05471B
ISSN: 2040-3364
2040-3372
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.