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DC Field | Value | Language |
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dc.contributor.author | JAIN, PRASHANT | en_US |
dc.contributor.author | SHANTHAMURTHY, CHETHAN D. | en_US |
dc.contributor.author | CHAUDHARY, PREETI MADHUKAR | en_US |
dc.contributor.author | KIKKERI, RAGHAVENDRA | en_US |
dc.date.accessioned | 2021-03-04T11:47:01Z | |
dc.date.available | 2021-03-04T11:47:01Z | |
dc.date.issued | 2021-03 | en_US |
dc.identifier.citation | Chemical Science, 12(11), 4021-4027. | en_US |
dc.identifier.issn | 2041-6539 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5695 | |
dc.identifier.uri | https://doi.org/10.1039/D1SC00140J | en_US |
dc.description.abstract | The aberrant expression of endocytic epidermal growth factor receptors (EGFRs) in cancer cells has emerged as a key target for therapeutic intervention. Here, we describe for the first time a state-of-the-art design for a heparan sulfate (HS) oligosaccharide-based nanovehicle to target EGFR-overexpressed cancer cells in cellular heterogeneity. An ELISA plate IC50 inhibition assay and surface plasma resonance (SPR) binding assay of structurally well-defined HS oligosaccharides showed that 6-O-sulfation (6-O-S) and 6-O-phosphorylation (6-O-P) of HS tetrasaccharides significantly enhanced EGFR cognate growth factor binding. The conjugation of these HS ligands to multivalent fluorescent gold nanoparticles (AuNPs) enabled the specific and efficient targeting of EGFR-overexpressed cancer cells. In addition, this heparinoid-nanovehicle exhibited selective homing to NPs in cancer cells in three-dimensional (3D) coculture spheroids, thus providing a novel target for cancer therapy and diagnostics in the tumor microenvironment (TME). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.subject | Chemistry | en_US |
dc.subject | 2021-MAR-WEEK1 | en_US |
dc.subject | TOC-MAR-2021 | en_US |
dc.subject | 2021 | en_US |
dc.title | Rational designing of glyco-nanovehicles to target cellular heterogeneity | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Chemistry | en_US |
dc.identifier.sourcetitle | Chemical Science | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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