Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5791
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dc.contributor.authorUlrich, Emily C.en_US
dc.contributor.authorKAMAT, SIDDHESH S.en_US
dc.contributor.authorHove-Jensen, Bjarneen_US
dc.contributor.authorZechel, David L.en_US
dc.date.accessioned2021-04-11T15:01:30Z-
dc.date.available2021-04-11T15:01:30Z-
dc.date.issued2018en_US
dc.identifier.citationMethods in Enzymology, Vol. 605, 351-426.en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5791-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0076687918300521?via%3Dihuben_US
dc.description.abstractInorganic phosphate is essential for all life forms, yet microbes in marine environments are in near constant deprivation of this important nutrient. Organophosphonic acids can serve as an alternative source of inorganic phosphate if microbes possess the appropriate biochemical pathways that allow cleavage of the stable carbon–phosphorus bond that defines this class of molecule. One prominent source of inorganic phosphate is methylphosphonic acid, which is found as a constituent of marine-dissolved organic matter. The cycle of biosynthesis and catabolism of methylphosphonic acid by marine microbes is the likely source of supersaturating levels of methane in shallow ocean waters. This review provides an overview of the rich biochemistry that has evolved to synthesize methylphosphonic acid and catabolize this molecule into Pi and methane, with an emphasis on the reactions catalyzed by methylphosphonic acid synthase MpnS and the carbon–phosphorus lyase system. The protocols and experiments that are described for MpnS and carbon–phosphorus lyase provide a foundation for studying the structures and mechanisms of these and related enzymes.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectPhosphonateen_US
dc.subjectMethylphosphonic acid synthaseen_US
dc.subjectCarbon—phosphorus lyaseen_US
dc.subjectMethane paradoxen_US
dc.subject2018en_US
dc.titleMethylphosphonic Acid Biosynthesis and Catabolism in Pelagic Archaea and Bacteriaen_US
dc.typeBook chapteren_US
dc.contributor.departmentDept. of Biologyen_US
dc.title.bookMarine Enzymes and Specialized Metabolism - Part Ben_US
dc.identifier.doihttps://doi.org/10.1016/bs.mie.2018.01.039en_US
dc.publication.originofpublisherForeignen_US
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