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Title: | Role of A‐ and B‐type lamins in nuclear structure–function relationships |
Authors: | PATIL, SHALAKA SENGUPTA, KUNDAN Dept. of Biology |
Keywords: | Gene expression Genome organisation Lamins Nucleus Nuclear envelope 2021-APR-WEEK3 TOC-APR-2021 2021 |
Issue Date: | Jul-2021 |
Publisher: | Wiley |
Citation: | Biology of the Cell, 113(7), 295-310. |
Abstract: | Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub‐population of A‐ and B‐type lamins localizes in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo‐cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilises protein–protein interactions involved in gene regulation and DNA repair. The lamin‐based protein sub‐complexes are implicated in both nuclear and cytoskeletal organisation, the mechanical stability of the nucleus, genome organisation, transcriptional regulation, genome stability and cellular differentiation. Here, we review recent research on nuclear lamins and unique roles of A‐ and B‐type lamins in modulating various nuclear processes and their impact on cell function. |
URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5830 https://doi.org/10.1111/boc.202000160 |
ISSN: | 0248-4900 1768-322X |
Appears in Collections: | JOURNAL ARTICLES |
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