Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5830
Title: Role of A‐ and B‐type lamins in nuclear structure–function relationships
Authors: PATIL, SHALAKA
SENGUPTA, KUNDAN
Dept. of Biology
Keywords: Gene expression
Genome organisation
Lamins
Nucleus
Nuclear envelope
2021-APR-WEEK3
TOC-APR-2021
2021
Issue Date: Jul-2021
Publisher: Wiley
Citation: Biology of the Cell, 113(7), 295-310.
Abstract: Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub‐population of A‐ and B‐type lamins localizes in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo‐cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilises protein–protein interactions involved in gene regulation and DNA repair. The lamin‐based protein sub‐complexes are implicated in both nuclear and cytoskeletal organisation, the mechanical stability of the nucleus, genome organisation, transcriptional regulation, genome stability and cellular differentiation. Here, we review recent research on nuclear lamins and unique roles of A‐ and B‐type lamins in modulating various nuclear processes and their impact on cell function.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5830
https://doi.org/10.1111/boc.202000160
ISSN: 0248-4900
1768-322X
Appears in Collections:JOURNAL ARTICLES

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