Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5839
Title: Influence of wet‐dry cycling on the self‐assembly and physicochemical properties of model protocellular membrane systems
Authors: SARKAR, SUSOVAN
DAGAR, SHIKHA
RAJAMANI, SUDHA
Dept. of Biology
Keywords: Self-assembly
Membranes
Protocells, Wet-Dry cycling
Molecular evolution
2021-APR-WEEK3
TOC-APR-2021
2021
Issue Date: Sep-2021
Publisher: Wiley
Citation: ChemSystemsChem, 3(5), e2100014.
Abstract: Wet‐dry cycles are hypothesized to facilitate fundamental steps towards the emergence of life on prebiotic Earth. Multiple wet‐dry cycles have been demonstrated to promote biopolymer formation. However, the effect of recurring wet‐dry cycles on the self‐assembly and physicochemical properties of model protocellular membranes remains somewhat obscure. Towards this end, we evaluated the structural and chemical stability of composite model protocell membrane systems composed of single chain amphiphiles, under wet‐dry cycles. The change in membrane properties, size and encapsulation was also investigated. Model protocellular membrane systems were found to reassemble into vesicles even over multiple cycling. Wet‐dry cycling induced compositional changes in the membranes, leading to changes in their physicochemical properties. Multiple cycles were also found to increase vesicular encapsulation of calcein. This work outlines how wet‐dry cycling on the early Earth could have helped in the formation of protocellular entities and their evolution on the prebiotic Earth.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5839
https://doi.org/10.1002/syst.202100014
ISSN: 2570-4206
Appears in Collections:JOURNAL ARTICLES

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