Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5883
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBARVE, APURVAen_US
dc.contributor.authorGalande, Alisha A.en_US
dc.contributor.authorGhaskadbi, Saroj S.en_US
dc.contributor.authorGhaskadbi, Surendraen_US
dc.date.accessioned2021-05-21T09:13:25Z
dc.date.available2021-05-21T09:13:25Z
dc.date.issued2021-04en_US
dc.identifier.citationFrontiers in Genetics, 12, 670695.en_US
dc.identifier.issn1664-8021en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5883
dc.identifier.urihttps://doi.org/10.3389/fgene.2021.670695en_US
dc.description.abstractSince its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of organismal senescence make hydra an intriguing animal to study. While a large body of work has taken place, particularly in the domain of evolutionary developmental biology of hydra, in recent years, the focus has shifted to molecular mechanisms underlying various phenomena. DNA repair is a fundamental cellular process that helps to maintain integrity of the genome through multiple repair pathways found across taxa, from archaea to higher animals. DNA repair capacity and senescence are known to be closely associated, with mutations in several repair pathways leading to premature ageing phenotypes. Analysis of DNA repair in an animal like hydra could offer clues into several aspects including hydra’s purported lack of organismal ageing, evolution of DNA repair systems in metazoa, and alternative functions of repair proteins. We review here the different DNA repair mechanisms known so far in hydra. Hydra genes from various DNA repair pathways show very high similarity with their vertebrate orthologues, indicating conservation at the level of sequence, structure, and function. Notably, most hydra repair genes are more similar to deuterostome counterparts than to common model invertebrates, hinting at ancient evolutionary origins of repair pathways and further highlighting the relevance of organisms like hydra as model systems. It appears that hydra has the full repertoire of DNA repair pathways, which are employed in stress as well as normal physiological conditions and may have a link with its observed lack of senescence. The close correspondence of hydra repair genes with higher vertebrates further demonstrates the need for deeper studies of various repair components, their interconnections, and functions in this early metazoan.en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjectHydraen_US
dc.subjectDNA repairen_US
dc.subjectEvolutionen_US
dc.subjectXeroderma pigmentosumen_US
dc.subjectNucleotide excision repair pathwayen_US
dc.subjectBase excision repairen_US
dc.subject2021-MAY-WEEK3en_US
dc.subjectTOC-MAY-2021en_US
dc.subject2021en_US
dc.titleDNA Repair Repertoire of the Enigmatic Hydraen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleFrontiers in Geneticsen_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.