Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6059
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dc.contributor.authorPANDEY, AKANKSHA M.en_US
dc.contributor.authorDIGRAWAL, NAVEEN KUMARen_US
dc.contributor.authorMOHANTA, NIRMALAen_US
dc.contributor.authorJAMDADE, AKASH BANDUen_US
dc.contributor.authorCHAUDHARI, MORESHWAR B.en_US
dc.contributor.authorBISHT, GIRISH SINGHen_US
dc.contributor.authorGNANAPRAKASAM, BOOPATHYen_US
dc.date.accessioned2021-07-09T10:36:32Z
dc.date.available2021-07-09T10:36:32Z
dc.date.issued2021-07en_US
dc.identifier.citationJournal of Organic Chemistry, 86(13), 8805–8828.en_US
dc.identifier.issn0022-3263en_US
dc.identifier.issn1520-6904en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6059-
dc.identifier.urihttps://doi.org/10.1021/acs.joc.1c00714en_US
dc.description.abstractA base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N-heterocycles by using 1,3-dicarbonyls and amino alcohols through a domino sequential enamine formation and intramolecular oxidative cyclization strategy. This unified approach is also applicable for the synthesis of O-heterocycles involving 2-hydroxybenzyl alcohol as a coupling reactant via consecutive C-alkylation and intramolecular cyclization steps. The present protocol is general for the synthesis of varieties of biologically important scaffolds, such as tetrahydro-4H-indol-4-one, 3,4-dihydroacridin-1(2H)-one, and tetrahydro-1H-xanthen-1-ones derivatives using a single catalytic system, viz. RuH2CO(PPh3)3. Environmentally benign H2O and H2 are the only byproducts in this domino process. Moreover, RuH2CO(PPh3)3-catalyzed C3-alkylation of tetrahydro-4H-indol-4-one using alcohol as a alkylating partner is also described in this report. For the first time, a solvent-free gram-scale reaction for the acceptorless dehydrogenative annulation has been demonstrated. A plausible mechanism for the Ru-catalyzed base-free and acceptorless dehydrogenative annulation of amino alcohols or 2-hydroxybenzyl alcohols has been provided with several experimental investigations and spectroscopic evidence.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectChemistryen_US
dc.subject2021-JUL-WEEK1en_US
dc.subjectTOC-JUL-2021en_US
dc.subject2021en_US
dc.titleCatalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditionsen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleJournal of Organic Chemistryen_US
dc.publication.originofpublisherForeignen_US
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