Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6129
Title: Rational Design of Programmable Monodisperse Semi-Synthetic Protein Nanomaterials Containing Engineered Disulfide Functionality
Authors: BHANDARI, PAVANKUMAR JANARDHAN
SANDANARAJ, BRITTO
Dept. of Chemistry
Keywords: Protein
Protein-dendron bioconjugates
2021-JUL-WEEK4
TOC-JUL-2021
2021
Issue Date: Oct-2021
Publisher: Wiley
Citation: ChemBioChem, 22(20), 2966-2972.
Abstract: The reversible nature of disulfide functionality has been exploited to design intelligent materials such as nanocapsules, micelles, vesicles, inorganic nanoparticles, peptide and nucleic acid nanodevices. Herein, we report a new chemical methodology for the construction redox-sensitive protein assemblies using monodisperse facially amphiphilic protein-dendron bioconjugates. The disulfide functionality is strategically placed between the dendron and protein domains. The custom designed bioconjugates self-assembled into nanoscopic objects of a defined size dictated by the nature of dendron domain. The stimuli-responsive behavior of the protein assemblies is demonstrated using a suitable redox trigger.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6129
https://doi.org/10.1002/cbic.202100288
ISSN: 1439-7633
Appears in Collections:JOURNAL ARTICLES

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