Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6204
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKANIGANTI, TARUNen_US
dc.contributor.authorDEOGADE, AJINKYAen_US
dc.contributor.authorMADUSKAR, ADITIen_US
dc.contributor.authorMUKHERJEE, ARGHYAen_US
dc.contributor.authorGURU, AKASHen_US
dc.contributor.authorSUBHEDAR, NISHIKANTen_US
dc.contributor.authorGHOSE, AURNABen_US
dc.date.accessioned2021-08-27T11:21:37Z
dc.date.available2021-08-27T11:21:37Z
dc.date.issued2021-12en_US
dc.identifier.citationJournal of Neurochemistry, 159(6), 1028-1044.en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn|1471-4159en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6204
dc.identifier.urihttps://doi.org/10.1111/jnc.15488en_US
dc.description.abstractModulation of sensory perception by homeostatic feedback from physiological states is central to innate purposive behaviors. Olfaction is an important predictive modality for feeding-related behaviors and its modulation has been associated with hunger-satiety states. However, the mechanisms mapping internal states to chemosensory processing in order to modify behavior are poorly understood. In the zebrafish olfactory epithelium, a subset of olfactory sensory neurons (OSNs) and the terminal nerve projections express neuropeptide Y (NPY). Using a combination of neuronal activity and behavioral evaluation, we find that NPY signaling in the peripheral olfactory system of zebrafish is correlated with its nutritional state and is both necessary and sufficient for the olfactory perception of food-related odorants. NPY activity dynamically modulates the microvillar OSN activation thresholds and acts cooperatively with amino acid signaling resulting in a switch-like increase in OSN sensitivity in starved animals. We suggest that cooperative activation of phospholipase C by convergent signaling from NPY and amino acid receptors is central to this heightened sensitivity. This study provides ethologically relevant, physiological evidence for NPY signaling in the modulation of OSN sensitivity to food-associated amino acid cues. We demonstrate sensory gating directly at the level of OSNs and identify a novel mechanistic framework for tuning olfactory sensitivity to prevailing energy states.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectNeuromodulationen_US
dc.subjectNeuropeptide Yen_US
dc.subjectNutritional stateen_US
dc.subjectOlfactory sensitivityen_US
dc.subjectOlfactory sensory neuronsen_US
dc.subject2021-AUG-WEEK4en_US
dc.subjectTOC-AUG-2021en_US
dc.subject2021en_US
dc.titleSensitivity of olfactory sensory neurons to food cues is tuned to nutritional states by Neuropeptide Y signalingen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleJournal of Neurochemistryen_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.