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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/642| Title: | Synthesis and Evaluation of Small Molecules Targeting miRNA-21 |
| Authors: | HOTHA, SRINIVAS DEVA NISHANTH, TIRUKOTI Dept. of Chemistry 20111064 |
| Keywords: | 2016 Chemical Biology miRNA-21 |
| Issue Date: | May-2016 |
| Abstract: | miRNA-21 (miR-21) plays vital role in many cancers, inflammation, cardiovascular diseases. Targeting miR-21 is challenging due to the lack of bio-resistant oligo antisense nucleotides. To overcome the problem, developments of small organic molecules which inhibit the biogenesis pathway of miRNA are sought. In this study, we came with small molecule peptoids that target miRNA-21 biogenesis pathway and looked at their efficacy by carrying biological studies using the MCF7 cancer cell line. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/642 |
| Appears in Collections: | MS THESES |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nishanth(20111064)_Master_thesis.pdf | 3.74 MB | Adobe PDF | View/Open |
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