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DC Field | Value | Language |
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dc.contributor.author | SHANTHAMURTHY, CHETHAN D. | en_US |
dc.contributor.author | Ben-Arye, Shani Leviatan | en_US |
dc.contributor.author | KUMAR, NANJUNDASWAMY VIJENDRA | en_US |
dc.contributor.author | Yehuda, Sharon | en_US |
dc.contributor.author | Amon, Ron | en_US |
dc.contributor.author | Woods, Robert J. | en_US |
dc.contributor.author | Padler-Karavani, Vered | en_US |
dc.contributor.author | KIKKERI, RAGHAVENDRA | en_US |
dc.date.accessioned | 2022-04-07T03:46:05Z | - |
dc.date.available | 2022-04-07T03:46:05Z | - |
dc.date.issued | 2021-03 | en_US |
dc.identifier.citation | Journal of Medicinal Chemistry, 64(6), 3367–3380. | en_US |
dc.identifier.issn | 0022-2623 | en_US |
dc.identifier.issn | 1520-4804 | en_US |
dc.identifier.uri | https://doi.org/10.1021/acs.jmedchem.0c01800 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/6725 | - |
dc.description.abstract | Achieving selective inhibition of chemokine activity by structurally well-defined heparan sulfate (HS) or HS mimetic molecules can provide important insights into their roles in individual physiological and pathological cellular processes. Here, we report a novel tailor-made HS mimetic, which furnishes an exclusive iduronic acid (IdoA) scaffold with different sulfation patterns and oligosaccharide chain lengths as potential ligands to target chemokines. Notably, highly sulfated-IdoA tetrasaccharide (I-45) exhibited strong binding to CCL2 chemokine thereby blocking CCL2/CCR2-mediated in vitro cancer cell invasion and metastasis. Taken together, IdoA-based HS mimetics offer an alternative HS substrate to generate selective and efficient inhibitors for chemokines and pave the way to a wide range of new therapeutic applications in cancer biology and immunology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.subject | Binding|Glycosaminoglycans | en_US |
dc.subject | Cxcr3 | en_US |
dc.subject | Oligomerization | en_US |
dc.subject | Recognition | en_US |
dc.subject | Expression | en_US |
dc.subject | 2021 | en_US |
dc.title | Heparan Sulfate Mimetics Differentially Affect Homologous Chemokines and Attenuate Cancer Development | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Chemistry | en_US |
dc.identifier.sourcetitle | Journal of Medicinal Chemistry | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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