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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7093| Title: | Chloride Transport across Liposomes and Cells by Nontoxic 3-(1H-1,2,3-Triazol-1-yl)benzamides |
| Authors: | MALLA, JAVID AHMAD UPADHYAY, AVISIKTA GHOSH, PULAK MONDAL, DEBASHIS MONDAL, ABHISHEK Sharma, Shilpy TALUKDAR, PINAKI Dept. of Chemistry |
| Keywords: | Anions Cell transport Charge transport Electrical transport Ions 2022-JUN-WEEK3 TOC-JUN-2022 2022 |
| Issue Date: | Jun-2022 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 24(23), 4124–4128. |
| Abstract: | Synthetic anion transmembrane transporters are adding new aspirations for treating channelopathies by replacing defective ion channels. The availability of such suitable candidates is still infrequent due to the associated toxicity. Here, we report 3-(1H-1,2,3-triazol-1-yl)benzamides as transmembrane anion carriers, nontoxic to cells. The selective and electrogenic chloride transport activity was established by fluorescence and ion selective electrode-based assays. MQAE assay confirmed the chloride uptake into the cells by the nontoxic compounds. |
| URI: | https://doi.org/10.1021/acs.orglett.2c01219 http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7093 |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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