Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151
Title: Small molecule NSAID derivatives for impairing powerhouse in cancer cells
Authors: Bajpai, Aman
DEEPSHIKHA
Chhabria, Dimple
Mishra, Tripti
Kirubakaran, Sivapriya
Basu, Sudipta
Dept. of Chemistry
Keywords: Mitochondria
Indomethacin
Ibuprofen
Cancer
2022-JUN-WEEK5
TOC-JUN-2022
2022
Issue Date: Jun-2022
Publisher: Elsevier B.V.
Citation: Bioorganic & Medicinal Chemistry, 64, 116759.
Abstract: Mitochondrion emerged as an important therapeutic target for anti-cancer strategy due to its involvement in cancer progression and development. However, progress of novel small molecules for selective targeting of mitochondria in cancer cells remained a major challenge. To address this, herein, through a concise synthetic strategy, we have synthesized a small molecule library of indomethacin and ibuprofen (non-steroidal anti-inflammatory drugs, NSAIDs) derivatives having triarylphosphonium moiety for mitochondria localization. Two of the library members were identified to induce mitochondrial damage through outer membrane permeabilization (MOMP) followed by generation of reactive oxygen species (ROS) leading to the remarkable MCF7 breast cancer cell death through apoptosis. These novel mitochondria targeted NSAID derivatives could open a new direction in understanding mitochondrial biology towards anti-cancer therapeutics in future.
URI: https://doi.org/10.1016/j.bmc.2022.116759
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151
ISSN: 0968-0896
Appears in Collections:JOURNAL ARTICLES

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