Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151
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dc.contributor.authorBajpai, Amanen_US
dc.contributor.authorDEEPSHIKHAen_US
dc.contributor.authorChhabria, Dimpleen_US
dc.contributor.authorMishra, Triptien_US
dc.contributor.authorKirubakaran, Sivapriyaen_US
dc.contributor.authorBasu, Sudiptaen_US
dc.date.accessioned2022-06-24T10:26:14Z
dc.date.available2022-06-24T10:26:14Z
dc.date.issued2022-06en_US
dc.identifier.citationBioorganic & Medicinal Chemistry, 64, 116759.en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2022.116759en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151
dc.description.abstractMitochondrion emerged as an important therapeutic target for anti-cancer strategy due to its involvement in cancer progression and development. However, progress of novel small molecules for selective targeting of mitochondria in cancer cells remained a major challenge. To address this, herein, through a concise synthetic strategy, we have synthesized a small molecule library of indomethacin and ibuprofen (non-steroidal anti-inflammatory drugs, NSAIDs) derivatives having triarylphosphonium moiety for mitochondria localization. Two of the library members were identified to induce mitochondrial damage through outer membrane permeabilization (MOMP) followed by generation of reactive oxygen species (ROS) leading to the remarkable MCF7 breast cancer cell death through apoptosis. These novel mitochondria targeted NSAID derivatives could open a new direction in understanding mitochondrial biology towards anti-cancer therapeutics in future.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectMitochondriaen_US
dc.subjectIndomethacinen_US
dc.subjectIbuprofenen_US
dc.subjectCanceren_US
dc.subject2022-JUN-WEEK5en_US
dc.subjectTOC-JUN-2022en_US
dc.subject2022en_US
dc.titleSmall molecule NSAID derivatives for impairing powerhouse in cancer cellsen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleBioorganic & Medicinal Chemistryen_US
dc.publication.originofpublisherForeignen_US
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