Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bajpai, Aman | en_US |
dc.contributor.author | DEEPSHIKHA | en_US |
dc.contributor.author | Chhabria, Dimple | en_US |
dc.contributor.author | Mishra, Tripti | en_US |
dc.contributor.author | Kirubakaran, Sivapriya | en_US |
dc.contributor.author | Basu, Sudipta | en_US |
dc.date.accessioned | 2022-06-24T10:26:14Z | |
dc.date.available | 2022-06-24T10:26:14Z | |
dc.date.issued | 2022-06 | en_US |
dc.identifier.citation | Bioorganic & Medicinal Chemistry, 64, 116759. | en_US |
dc.identifier.issn | 0968-0896 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.bmc.2022.116759 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7151 | |
dc.description.abstract | Mitochondrion emerged as an important therapeutic target for anti-cancer strategy due to its involvement in cancer progression and development. However, progress of novel small molecules for selective targeting of mitochondria in cancer cells remained a major challenge. To address this, herein, through a concise synthetic strategy, we have synthesized a small molecule library of indomethacin and ibuprofen (non-steroidal anti-inflammatory drugs, NSAIDs) derivatives having triarylphosphonium moiety for mitochondria localization. Two of the library members were identified to induce mitochondrial damage through outer membrane permeabilization (MOMP) followed by generation of reactive oxygen species (ROS) leading to the remarkable MCF7 breast cancer cell death through apoptosis. These novel mitochondria targeted NSAID derivatives could open a new direction in understanding mitochondrial biology towards anti-cancer therapeutics in future. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.subject | Mitochondria | en_US |
dc.subject | Indomethacin | en_US |
dc.subject | Ibuprofen | en_US |
dc.subject | Cancer | en_US |
dc.subject | 2022-JUN-WEEK5 | en_US |
dc.subject | TOC-JUN-2022 | en_US |
dc.subject | 2022 | en_US |
dc.title | Small molecule NSAID derivatives for impairing powerhouse in cancer cells | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Chemistry | en_US |
dc.identifier.sourcetitle | Bioorganic & Medicinal Chemistry | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.