Please use this identifier to cite or link to this item:
Title: Modeling the Spatial Pattern Forming Modules in Mitotic Spindle Assembly
Dubitzky, Werner
Southgate, Jennifer
Fuß, Hendrik
Dept. of Biology
Keywords: Mitotic Spindle
Spindle Assembly
Microtubule Dynamic
Nucleate Microtubule
Astral Microtubule
Issue Date: Dec-2010
Publisher: Springer Nature
Citation: Understanding the Dynamics of Biological Systems, 155–173.
Abstract: The mitotic microtubule-based spindle that separates genetic material at cell division in eukaryotic cells is an example of robust pattern formation that leads to structure for a critical function- cell division. Microtubule dynamics, motor interactions with the microtubule cytoskeleton and chromosomal dynamics have been shown in experiment and simulation to produce a variety of patterns. Recently however the role of chromosomal regulatory gradient has also begun to be explored. We can show that an iterative cycle of model-building, simulation, experimental design and quantification brings us closer to a “systems level” understanding of the modules that contribute to the assembly of the mitotic spindle as a whole.
ISBN: 978-1-4419-7964-3
Appears in Collections:BOOK CHAPTERS

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.