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DC Field | Value | Language |
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dc.contributor.author | NISAL, RAHUL | en_US |
dc.contributor.author | JAYAKANNAN, MANICKAM | en_US |
dc.date.accessioned | 2022-07-01T03:57:07Z | - |
dc.date.available | 2022-07-01T03:57:07Z | - |
dc.date.issued | 2022-06 | en_US |
dc.identifier.citation | Biomacromolecules, 23(6), 2667-2684. | en_US |
dc.identifier.issn | 1525-7797 | en_US |
dc.identifier.issn | 1526-4602 | en_US |
dc.identifier.uri | https://doi.org/10.1021/acs.biomac.2c00416 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7221 | - |
dc.description.abstract | β-Sheet forming polypeptides are one of the least explored synthetic systems due to their uncontrolled precipitation in the ring-opening polymerization (ROP) synthetic methodology. Here, a new t-butylbenzene functionalization approach is introduced to overcome this limitation by sterically controlling the propagating polymer chains, and homogeneous polymerization with good control over chain growth was accomplished. New bulky N-carboxyanhydride monomers were designed having t-butylbenzene pendant by multistep organic synthesis, and N-heterocyclic carbene was explored as a catalyst to make high-molecular-weight and narrow polydisperse soluble polypeptides. This ROP process was successfully demonstrated for two β-sheet forming polypeptides such as poly(l-serine) and poly(l-cysteine). These new t-butylbenzene-functionalized polypeptides were found to be readily soluble in tetrahydrofuran, chloroform, and so forth, and they were produced in high molecular weights having Mn = 32 kDa with dispersity D̵ ≤ 1.3. ROP kinetics were studied by real-time Fourier transform infrared and 1H NMR to determine the actual content of the secondary structures in the propagating chains. These studies established that the α-helical conformational front in the propagation chain was speeding up the polymerization kinetics with good degree of control in the ROP process. Reversible-conformational transitions in the post-polymerization deprotection were found to restore the β-sheet secondary structures in poly(l-serine)s. The newly developed t-butylbenzene-substituted steric-hindrance approach is valuable in yielding soluble polymers, and this approach could be useful for exploring new polypeptide architectures for long-term impact. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.subject | Anions | en_US |
dc.subject | Ethyl groups | en_US |
dc.subject | Mixtures | en_US |
dc.subject | Solutions | en_US |
dc.subject | 2022-JUN-WEEK5 | en_US |
dc.subject | TOC-JUN-2022 | en_US |
dc.subject | 2022 | en_US |
dc.title | Tertiary-Butylbenzene Functionalization as a Strategy for fl-Sheet Polypeptides | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Chemistry | en_US |
dc.identifier.sourcetitle | Biomacromolecules | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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