Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7257
Title: Direct access to spirooxindole dihydropyrrole fused pyrazolones and bis-spiropyrazolone derivatives
Authors: WARGHUDE, PRAKASH K.
BHOWMICK, ANINDITA
BHAT, RAMAKRISHNA G.
Dept. of Chemistry
Keywords: Annulation
Bis-spiropyrazolones
Diastereoselective
MBH carbonate
Spirooxindole
2022-JUL-WEEK2
TOC-JUL-2022
2022
Issue Date: May-2022
Publisher: Elsevier B.V.
Citation: Tetrahedron Letters, 97, 153791.
Abstract: A highly regio- and diastereo-selective [3 + 2] annulation of Morita–Baylis–Hillman carbonates of isatins/pyrazolones with pyrazolone derived ketimines has been developed to access spiroheterocycles. The protocol worked effectively to construct spirooxindole dihydropyrrole fused pyrazolone and bis-spiropyrazolone dihydropyrrole derivatives bearing two vicinal quaternary spirocentres in good to excellent yields with very high diastereoselectivities under mild catalytic condition at room temperature. The protocol proved to be efficient with diverse MBH carbonates and ketimine derivatives. The method has successfully demonstrated the utility of DMAP as the commercially viable catalyst for this transformation.
URI: https://doi.org/10.1016/j.tetlet.2022.153791
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7257
ISSN: 0040-4039
1873-3581
Appears in Collections:JOURNAL ARTICLES

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