Structural Control of Peptide Nucleic Acid Rotamers: Aza-PNA and Optical Properties of Gemdimethyl PNA, Bimodal PNA Monomers and Oligomers

Abstract

The thesis entitled “Structural control of Peptide Nucleic Acid (PNA) rotamers and their fluorescence properties: aza-PNA, gemdimethyl G-PNA and Cα(S)-bm PNA monomers and oligomers” describes studies done on the synthesis, characterisation and rotamer study of novel aza-PNA monomers, α/β-gemdimethyl guanine PNA, Cα(S)-(acetamido)-bm PNA monomers and oligomers. The effect of intramolecular H-bonding in Cα-NH (aza-PNA) and gem-dimethyl substitution induced conformational constraint on rotamer selectivity and the fluorescence properties are explored in this work. The thesis is presented in five chapters.