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DC Field | Value | Language |
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dc.contributor.author | JOSHI, MANESH PRAKASH | en_US |
dc.contributor.author | UDAY, ASHWIN | en_US |
dc.contributor.author | RAJAMANI, SUDHA | en_US |
dc.date.accessioned | 2022-11-14T04:05:46Z | |
dc.date.available | 2022-11-14T04:05:46Z | |
dc.date.issued | 2022-11 | en_US |
dc.identifier.citation | Communications Chemistry, 5, 147. | en_US |
dc.identifier.issn | 2399-3669 | en_US |
dc.identifier.uri | https://doi.org/10.1038/s42004-022-00762-9 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7458 | |
dc.description.abstract | Protoamphiphiles are prebiotically-plausible moieties that would have constituted protocell membranes on early Earth. Although prebiotic soup would have contained a diverse set of amphiphiles capable of generating protocell membranes, earlier studies were mainly limited to fatty acid-based systems. Herein, we characterize N-acyl amino acids (NAAs) as a model protoamphiphilic system. To the best of our knowledge, we report a new abiotic route in this study for their synthesis under wet-dry cycles from amino acids and monoglycerides via an ester-amide exchange process. We also demonstrate how N-oleoyl glycine (NOG, a representative NAA) results in vesicle formation over a broad pH range when blended with a monoglyceride or a fatty acid. Notably, NOG also acts as a substrate for peptide synthesis under wet-dry cycles, generating different lipopeptides. Overall, our study establishes NAAs as a promising protoamphiphilic system, and highlights their significance in generating robust and functional protocell membranes on primitive Earth. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.subject | Lipids | en_US |
dc.subject | Chemical origin of life | en_US |
dc.subject | 2022-NOV-WEEK1 | en_US |
dc.subject | TOC-NOV-2022 | en_US |
dc.subject | 2022 | en_US |
dc.title | Elucidating N-acyl amino acids as a model protoamphiphilic system | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Biology | en_US |
dc.identifier.sourcetitle | Communications Chemistry | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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