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DC Field | Value | Language |
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dc.contributor.author | Vaid, Pooja M. | en_US |
dc.contributor.author | SHASHIDHARA, L. S. et al. | en_US |
dc.date.accessioned | 2022-12-09T05:55:58Z | |
dc.date.available | 2022-12-09T05:55:58Z | |
dc.date.issued | 2022-12 | en_US |
dc.identifier.citation | Diagnostic Pathology, 17, 91. | en_US |
dc.identifier.issn | 1746-1596 | en_US |
dc.identifier.uri | https://doi.org/10.1186/s13000-022-01271-y | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7488 | |
dc.description.abstract | Objectives Evaluation of tumor-infiltrating lymphocytes (TILs) distribution in an Indian cohort of breast cancer patients for its prognostic significance. Methods A retrospective cohort of breast cancer patients from a single onco-surgeon’s breast cancer clinic with a uniform treatment strategy was evaluated for TILs. Tumor sections were H&E stained and scored for the spatial distribution and percent stromal TILs infiltration by a certified pathologist. The scores were analysed for association with treatment response and survival outcomes across molecular subtypes. Results Total 229 breast cancer tumors were evaluated. Within spatial distribution categories, intra-tumoral TILs were observed to be associated with complete pathological response and lower recurrence frequency for the entire cohort. Subtype-wise analysis of stromal TILs (sTILs) re-enforced significantly higher infiltration in TNBC compared to HER2-positive and ER-positive tumors. A favourable association of higher stromal infiltration was observed with treatment response and disease outcomes, specifically in TNBC. Conclusion Intra-tumoral TILs showed a higher proportion with favourable association with better patient outcomes in an Indian cohort, unlike western cohorts where both stromal and intra-tumoral TILs show similar association with prognosis. With further validation, TILs can be developed as a cost-effective surrogate marker for treatment response, especially in a low-resource setting such as India. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd | en_US |
dc.subject | TILs | en_US |
dc.subject | TNBC | en_US |
dc.subject | Breast Cancer in India | en_US |
dc.subject | 2022-DEC-WEEK1 | en_US |
dc.subject | TOC-DEC-2022 | en_US |
dc.subject | 2022 | en_US |
dc.title | Evaluation of tumor-infiltrating lymphocytes (TILs) in molecular subtypes of an Indian cohort of breast cancer patients | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Biology | en_US |
dc.identifier.sourcetitle | Diagnostic Pathology | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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