Aza-PNA: Engineering E-Rotamer Selectivity Directed by Intramolecular H-bonding

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7542

Title:	Aza-PNA: Engineering E-Rotamer Selectivity Directed by Intramolecular H-bonding
Authors:	SHIRAJ, ABDUL Ramabhadran, Raghunath O. GANESH, KRISHNA N. Dept. of Chemistry
Keywords:	Amides Chemical structure Nuclear magnetic resonance spectroscopy Organic compounds Solvents 2022-DEC-WEEK3 TOC-DEC-2022 2022
Issue Date:	Oct-2022
Publisher:	American Chemical Society
Citation:	Organic Letters, 24(40), 7421–7427.
Abstract:	The replacement of α(CH2) by NH in monomers of standard aeg PNA and its homologue β-ala PNA leads to respective aza-PNA monomers (1 and 2) in which the NαH can form either an 8-membered H-bonded ring with folding of the backbone (DMSO and water) or a 5-membered NαH─αCO (water) to stabilize E-type rotamers. Such aza-PNA oligomers with exclusive E rotamers and intraresidue backbone H-bonding can modulate its DNA/RNA binding and assembling properties.
URI:	https://doi.org/10.1021/acs.orglett.2c02993 http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7542
ISSN:	1523-7060 1523-7052
Appears in Collections:	JOURNAL ARTICLES

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