Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7618
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dc.contributor.authorPATIL, SHALAKAen_US
dc.contributor.authorDESHPANDE, SHRUTIen_US
dc.contributor.authorSENGUPTA, KUNDANen_US
dc.date.accessioned2023-02-20T05:49:16Z
dc.date.available2023-02-20T05:49:16Z
dc.date.issued2023-03en_US
dc.identifier.citationHuman Molecular Genetics, 32(5), 745–763.en_US
dc.identifier.issn0964-6906en_US
dc.identifier.issn1460-2083en_US
dc.identifier.urihttps://doi.org/10.1093/hmg/ddac235en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7618
dc.description.abstractLamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects accompanied by recurrent chromosomal losses. In addition, LBR knockdown results in nuclear aberrations such as nuclear blebs and micronuclei, with chromosomes showing higher frequency of losses, being enriched within the micronucleus. Furthermore, doxycycline-induced conditional depletion of LBR significantly increased tumor volumes that form within the subcutaneous xenografts of mice. Of note, the tumor-derived primary cells recapitulated chromosomal losses and gains, revealing a novel role for LBR as a tumor suppressor. Co-immunoprecipitation of LBR uncovered an association of LBR with telomere-associated factors. Interestingly, qPCR array-based gene expression profiling showed a significant upregulation of telomere repeat-binding factor 1 (TRF1) upon LBR depletion. Remarkably, TRF1 knockdown in the background of LBR depletion maintains chromosomal stability, unraveling a novel mechanism involving LBR and TRF in the maintenance of chromosomal stability in colorectal cancer cells.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectMediated Regulationen_US
dc.subjectColorectal-Canceren_US
dc.subjectAurora-Ben_US
dc.subject2023-FEB-WEEK2en_US
dc.subjectTOC-FEB-2023en_US
dc.subject2023en_US
dc.titleNuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesisen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleHuman Molecular Geneticsen_US
dc.publication.originofpublisherForeignen_US
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