Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7684
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dc.contributor.authorKUMARI, POOJAen_US
dc.contributor.authorKaul, Graceen_US
dc.contributor.authorKUMAR, T. ANANDen_US
dc.contributor.authorAkhir, Abdulen_US
dc.contributor.authorShukla, Manjulikaen_US
dc.contributor.authorSHARMA, SURAJen_US
dc.contributor.authorKAMAT, SIDDHESH S.en_US
dc.contributor.authorChopra, Sidharthen_US
dc.contributor.authorCHAKRAPANI, HARINATHen_US
dc.date.accessioned2023-03-31T09:43:50Z
dc.date.available2023-03-31T09:43:50Z
dc.date.issued2023-04en_US
dc.identifier.citationMicrobiology Spectrum, 11(02).en_US
dc.identifier.issn2165-0497en_US
dc.identifier.urihttps://doi.org/10.1128/spectrum.04773-22en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7684
dc.description.abstractFinding new therapeutic strategies against Gram-negative pathogens such as Acinetobacter baumannii is challenging. Starting from diphenyleneiodonium (dPI) salts, which are moderate Gram-positive antibacterials, we synthesized a focused heterocyclic library and found a potent inhibitor of patient-derived multidrug-resistant Acinetobacter baumannii strains that significantly reduced bacterial burden in an animal model of infection caused by carbapenem-resistant Acinetobacter baumannii (CRAB), listed as a priority 1 critical pathogen by the World Health Organization. Next, using advanced chemoproteomics platforms and activity-based protein profiling (ABPP), we identified and biochemically validated betaine aldehyde dehydrogenase (BetB), an enzyme that is involved in the metabolism and maintenance of osmolarity, as a potential target for this compound. Together, using a new class of heterocyclic iodonium salts, a potent CRAB inhibitor was identified, and our study lays the foundation for the identification of new druggable targets against this critical pathogen.en_US
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.subjectBiologyen_US
dc.subject2023-MAR-WEEK4en_US
dc.subjectTOC-MAR-2023en_US
dc.subject2023en_US
dc.titleHeterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumanniien_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleMicrobiology Spectrumen_US
dc.publication.originofpublisherForeignen_US
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