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DC Field | Value | Language |
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dc.contributor.advisor | HOTHA, SRINIVAS | - |
dc.contributor.author | DAS, ARITRA | - |
dc.date.accessioned | 2023-05-18T11:16:17Z | - |
dc.date.available | 2023-05-18T11:16:17Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.citation | 51 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7920 | - |
dc.description.abstract | Glycosylation is a fundamental reaction in organic chemistry that involves the attachment of a sugar moiety to a non-sugar molecule, such as a steroid or a protein. This ubiquitous biological process is observed across all living organisms and performs vital functions such as facilitating cell-cell recognition, signal transduction, and immune responses. Additionally, glycosylation can modulate the properties of biomolecules, such as their solubility, stability, and bioactivity making it a valuable tool for drug discovery and development. Protodioscin is a natural steroid saponin that has attracted attention for its pharmacological properties, which include anti-inflammatory, anticancer, and anti-diabetic effects. However, its isolation from natural sources is complex and inefficient, making chemical synthesis an attractive alternative. In this study, I developed a gold-catalyzed glycosylation approach for synthesising protodioscin from readily available starting materials. The synthesis involved using a gold(I) catalyst and a glycosyl donor to selectively activate the C-3 position of a steroid precursor, followed by regio- and stereoselective glycosylation at the C-26 position. The reaction was optimised using a range of reaction conditions. My results demonstrate an elementary, proficient, and scalable approach for the synthesis of protodioscin, which has the potential to facilitate its further investigation as a therapeutic agent. | en_US |
dc.language.iso | en | en_US |
dc.subject | Research Subject Categories::MEDICINE | en_US |
dc.subject | Research Subject Categories::NATURAL SCIENCES | en_US |
dc.subject | Research Subject Categories::PHARMACY | en_US |
dc.title | SYNTHESIS OF PROTODIOSCIN | en_US |
dc.type | Thesis | en_US |
dc.description.embargo | One Year | en_US |
dc.type.degree | BS-MS | en_US |
dc.contributor.department | Dept. of Chemistry | en_US |
dc.contributor.registration | 20181140 | en_US |
Appears in Collections: | MS THESES |
Files in This Item:
File | Description | Size | Format | |
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20181140_Aritra_Das_MS_Thesis | MS Thesis | 1.44 MB | Adobe PDF | View/Open |
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