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Title: | Supramolecular Barrel-Rosette Ion Channel Based on 3,5-Diaminobenzoic Acid for Cation-Anion Symport |
Authors: | CHATTOPADHAYAY, SANDIP Ghosh, Anupam Mukhopadhyay, Titas Kumar SHARMA, RASHMI Datta, Ayan TALUKDAR, PINAKI Dept. of Chemistry |
Keywords: | Cations and Anions Charge Transport Ion Channel Membranes Symport 2023-NOV-WEEK1 TOC-NOV-2023 2023 |
Issue Date: | Nov-2023 |
Publisher: | Wiley |
Citation: | Angewandte Chemie-International Edition, 62(46), e202313712. |
Abstract: | The structural tropology and functions of natural cation-anion symporting channels have been continuously investigated due to their crucial role in regulating various physiological functions. To understand the physiological functions of the natural symporter channels, it is vital to develop small-molecule-based biomimicking systems that can provide mechanistic insights into the ion-binding sites and the ion-translocation pathways. Herein, we report a series of bis((R)-(-)-mandelic acid)-linked 3,5-diaminobenzoic acid based self-assembled ion channels with distinctive ion transport ability. Ion transport experiment across the lipid bilayer membrane revealed that compound 1 b exhibits the highest transport activity among the series, and it has interesting selective co-transporting functions, i.e., facilitates K+/ClO(4)(- )symport. Electrophysiology experiments confirmed the formation of supramolecular ion channels with an average diameter of 6.2 +/- 1 & Aring; and single channel conductance of 57.3 +/- 1.9 pS. Selectivity studies of channel 1 b in a bilayer lipid membrane demonstrated a permeability ratio of PCl-/PK+ -0:053 +/- 0:02, PCl4-/PCl--2:1 +/- 0:5, and indicating the higher selectivity of the channel towards KClO4 over KCl salt. A hexameric assembly of a trimeric rosette of 1 b was subjected to molecular dynamics simulations with different salts to understand the supramolecular channel formation and ion selectivity pattern. |
URI: | https://doi.org/10.1002/anie.202313712 http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8277 |
ISSN: | 1433-7851 1521-3773 |
Appears in Collections: | JOURNAL ARTICLES |
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