Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8650
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dc.contributor.authorSehgal, Manasen_US
dc.contributor.authorRay, Ritojaen_US
dc.contributor.authorVaz, Joel Markusen_US
dc.contributor.authorKANIKAR, SHRIHARen_US
dc.contributor.authorSomarelli, Jason A.en_US
dc.contributor.authorJolly, Mohit Kumaren_US
dc.date.accessioned2024-04-24T05:42:06Z-
dc.date.available2024-04-24T05:42:06Z-
dc.date.issued2023-07en_US
dc.identifier.citationAdvances in Cancer Biology - Metastasis, 7, 100091.en_US
dc.identifier.issn2667-3940en_US
dc.identifier.urihttps://doi.org/10.1016/j.adcanc.2023.100091en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8650-
dc.description.abstractOncoviruses exploit diverse host mechanisms to survive and proliferate. These adaptive strategies overlap with mechanisms employed by malignant cells during their adaptation to dynamic micro-environments and for evasion of immune attack. While the role of individual oncoviruses in mediating cancer progression has been extensively characterized, little is known about the common gene regulatory features of oncovirus-induced cancers. Here, we focus on defining the interplay between several cancer hallmarks, including Epithelial-Mesenchymal Transition (EMT), metabolic alterations, and immune evasion across major oncoviruses by examining publicly available transcriptomics datasets containing both oncovirus-positive and oncovirus-negative samples. We observe that oncovirus-positive samples display varying degrees of EMT and metabolic reprogramming. While the progression of EMT generally associated with an enriched glycolytic metabolic program and suppressed fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS), partial EMT correlated well with glycolysis. Furthermore, oncovirus-positive samples had higher activity and/or expression levels of immune checkpoint molecules, such as PD-L1, which was associated with a partial EMT program. These analyses thus decode common pathways in oncovirus-positive samples that may be used in pinpointing new therapeutic vulnerabilities for cancer cell plasticity.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectOncovirusen_US
dc.subjectEMTen_US
dc.subjectPD-L1en_US
dc.subjectMetabolic reprogrammingen_US
dc.subjectOxidative phosphorylationen_US
dc.subjectFatty acid metabolismen_US
dc.subjectGlycolysisen_US
dc.subject2023en_US
dc.titlePartial EMT and associated changes in cellular plasticity in oncovirus-positive samplesen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleAdvances in Cancer Biology - Metastasisen_US
dc.publication.originofpublisherForeignen_US
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