Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8749
Title: Editing of N-Glycans for Active Pharmaceutical Ingredients
Authors: HOTHA, SRINIVAS
KUNDU, SUMAN
Dept. of Chemistry
20212015
Keywords: Editing
Nucleoside
Issue Date: May-2024
Citation: 75
Abstract: Analogues of nucleosides are highly significant in the realm of small molecule pharmaceuticals, serving as essential constituents in biological systems and playing a crucial role in treating cancer and viral infections as effective therapeutic agents. Synthesis of nucleosides in a cost-effective way from readily accessible starting material is still a formidable challenge, despite their widespread presence in DNA or RNA. Herein, we report the synthesis of purine and pyrimidine nucleosides using commercially available purine nucleosides through a one-step chemical transglycosylation approach. The method demonstrates effectiveness, selectivity, and wide applicability, facilitating easy synthesis of various complex O- S-, and N-glycosides in a streamlined fashion. Significantly, this editing strategy was further demonstrated by the syntheses of nucleoside antibiotics Ribavirin, 5-azacytidine, and Tubercidin.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8749
Appears in Collections:MS THESES

Files in This Item:
File Description SizeFormat 
20212015_Suman_Kundu_MS_Thesis.pdfMS Thesis8.42 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.