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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8749
Title: | Editing of N-Glycans for Active Pharmaceutical Ingredients |
Authors: | HOTHA, SRINIVAS KUNDU, SUMAN Dept. of Chemistry 20212015 |
Keywords: | Editing Nucleoside |
Issue Date: | May-2024 |
Citation: | 75 |
Abstract: | Analogues of nucleosides are highly significant in the realm of small molecule pharmaceuticals, serving as essential constituents in biological systems and playing a crucial role in treating cancer and viral infections as effective therapeutic agents. Synthesis of nucleosides in a cost-effective way from readily accessible starting material is still a formidable challenge, despite their widespread presence in DNA or RNA. Herein, we report the synthesis of purine and pyrimidine nucleosides using commercially available purine nucleosides through a one-step chemical transglycosylation approach. The method demonstrates effectiveness, selectivity, and wide applicability, facilitating easy synthesis of various complex O- S-, and N-glycosides in a streamlined fashion. Significantly, this editing strategy was further demonstrated by the syntheses of nucleoside antibiotics Ribavirin, 5-azacytidine, and Tubercidin. |
URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/8749 |
Appears in Collections: | MS THESES |
Files in This Item:
File | Description | Size | Format | |
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20212015_Suman_Kundu_MS_Thesis.pdf | MS Thesis | 8.42 MB | Adobe PDF | View/Open Request a copy |
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