Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9271
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dc.contributor.authorSarkar, Binayaken_US
dc.contributor.authorCHANDRAMOULI, AAKASHen_US
dc.contributor.authorKAMAT, SIDDHESH S.en_US
dc.contributor.authorGOKHALE, RAJESH S. et al.en_US
dc.date.accessioned2025-01-31T06:27:57Z
dc.date.available2025-01-31T06:27:57Z
dc.date.issued2025-01en_US
dc.identifier.citationMicrobiology and Infectious Disease.en_US
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttps://doi.org/10.7554/eLife.103817.1en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9271
dc.description.abstractMycobacterium tuberculosis (Mtb) infection of the lungs, besides producing prolonged cough with mucus, also causes progressive fatigue and cachexia with debilitating loss of muscle mass. While anti-tuberculosis (TB) drug therapy is directed toward eliminating bacilli, the treatment regimen ignores the systemic pathogenic derailments that probably dictate TB-associated mortality and morbidity. Presently, it is not understood whether Mtb spreads to metabolic organs and brings about these impairments. Here we show that Mtb creates a replication-conducive milieu of lipid droplets in hepatocytes by upregulating transcription factor PPARγ and scavenging lipids from the host cells. In hepatocytes, Mtb shields itself against the common anti-TB drugs by inducing drug-metabolizing enzymes. Infection of the hepatocytes in the in vivo aerosol mice model can be consistently observed post-week 4 along with enhanced expression of PPARγ and drug-metabolizing enzymes. Moreover, histopathological analysis indeed shows the presence of Mtb in hepatocytes along with granuloma-like structures in human biopsied liver sections. Hepatotropism of Mtb during the chronic infectious cycle results in immuno-metabolic dysregulation that could magnify local and systemic pathogenicity, altering clinical presentations.en_US
dc.language.isoenen_US
dc.publishereLife Sciences Publications Ltd.en_US
dc.subjectMycobacterium tuberculosisen_US
dc.subject2025-JAN-WEEK1|TOC-JAN-2025en_US
dc.subject2025en_US
dc.titlePPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environmenten_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleeLifeen_US
dc.publication.originofpublisherForeignen_US
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