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DC Field | Value | Language |
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dc.contributor.author | Sarkar, Binayak | en_US |
dc.contributor.author | CHANDRAMOULI, AAKASH | en_US |
dc.contributor.author | KAMAT, SIDDHESH S. | en_US |
dc.contributor.author | GOKHALE, RAJESH S. et al. | en_US |
dc.date.accessioned | 2025-01-31T06:27:57Z | |
dc.date.available | 2025-01-31T06:27:57Z | |
dc.date.issued | 2025-01 | en_US |
dc.identifier.citation | Microbiology and Infectious Disease. | en_US |
dc.identifier.issn | 2050-084X | en_US |
dc.identifier.uri | https://doi.org/10.7554/eLife.103817.1 | en_US |
dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9271 | |
dc.description.abstract | Mycobacterium tuberculosis (Mtb) infection of the lungs, besides producing prolonged cough with mucus, also causes progressive fatigue and cachexia with debilitating loss of muscle mass. While anti-tuberculosis (TB) drug therapy is directed toward eliminating bacilli, the treatment regimen ignores the systemic pathogenic derailments that probably dictate TB-associated mortality and morbidity. Presently, it is not understood whether Mtb spreads to metabolic organs and brings about these impairments. Here we show that Mtb creates a replication-conducive milieu of lipid droplets in hepatocytes by upregulating transcription factor PPARγ and scavenging lipids from the host cells. In hepatocytes, Mtb shields itself against the common anti-TB drugs by inducing drug-metabolizing enzymes. Infection of the hepatocytes in the in vivo aerosol mice model can be consistently observed post-week 4 along with enhanced expression of PPARγ and drug-metabolizing enzymes. Moreover, histopathological analysis indeed shows the presence of Mtb in hepatocytes along with granuloma-like structures in human biopsied liver sections. Hepatotropism of Mtb during the chronic infectious cycle results in immuno-metabolic dysregulation that could magnify local and systemic pathogenicity, altering clinical presentations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | eLife Sciences Publications Ltd. | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | 2025-JAN-WEEK1|TOC-JAN-2025 | en_US |
dc.subject | 2025 | en_US |
dc.title | PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment | en_US |
dc.type | Article | en_US |
dc.contributor.department | Dept. of Biology | en_US |
dc.identifier.sourcetitle | eLife | en_US |
dc.publication.originofpublisher | Foreign | en_US |
Appears in Collections: | JOURNAL ARTICLES |
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