Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9421
Title: A randomized phase II/III trial of rosuvastatin with neoadjuvant chemo-radiation in patients with locally advanced rectal cancer
Authors: GUPTA, EKTA
GALANDE, SANJEEV et. al.
Dept. of Biology
Keywords: rosuvastatin
Pathological complete response
Neoadjuvant chemoradiation
Rectal cancer
drug repurposing
2025-MAR-WEEK4
TOC-MAR-2025
2025
Issue Date: Mar-2025
Publisher: Frontiers
Citation: Frontiers in Oncology, 15.
Abstract: Statins have been shown to improve the possibility of a pathological complete response (pCR) in patients with locally advanced rectal cancer when given in combination with neo-adjuvant chemo-radiation (NACTRT) in observational studies. The primary objective of this phase II randomized controlled trial (RCT) is to determine the impact of rosuvastatin in improving pCR rates in patients with locally advanced rectal cancer who are undergoing NACTRT. The secondary objectives are to compare adverse events, postoperative morbidity and mortality, disease-free survival (DFS), and overall survival in the two arms and to identify potential prognostic and predictive factors determining outcomes. If the study is positive, we plan to proceed to a phase III RCT with 3-year DFS as the primary endpoint.
URI: https://doi.org/10.3389/fonc.2025.1450602
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/9421
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