Stereoselective synthesis of spirooxindole scaffold

Abstract

Continual research progress in organic and medicinal chemistry emphasizes the critical goal of devising and developing innovative synthetic methodologies for constructing novel chemical entities with high stereoselectivity. This book chapter delves into the evolution of stereoselective strategies targeting spirocyclic oxindoles, encompassing spiro-rings ranging from three- to eight-members in size. It underscores the paramount significance of these structural motifs in medicinal chemistry, where they serve as vital intermediates or useful final compounds the endeavors of total synthesis. Furthermore, spirocyclic oxindoles serve as pivotal model compounds in the advancement of enantioselective catalytic methodologies. This book chapter provides an in-depth review of the advancements in this field, highlighting their profound implications in both synthetic chemistry and drug discovery.