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Fitness Effects of Changing Codon Bias of two genes – mauA and mtdA in Methylobacterium extorquens AM1

WALUNJKAR, NILIMA (2017-04)

Organisms have a codon bias i.e. they use certain codons more frequently than others that code for the same amino acid. Studies have shown that changing the codon bias of a gene can have a negative impact on fitness due ...
Effects of mutation rate and bias on bacterial mutator dynamics

PRATYUSH, M R (2022-05)

The impact of mutation rate on evolutionary dynamics has been well-studied. It is well-known that an increased mutation rate, seen in mutator strains of bacteria, speeds up adaptation to novel environments. However, mutators ...
Impact of Mutation Rate and Bias on Bacterial Adaptation in Fluctuating Environments

LAHIRI, KUSHAN (2023-05)

We use the term ‘mutation spectrum’ to refer to the frequency distribution of the types of mutations that an organism tends to undergo overtime. However, more often than not, this mutation spectrum tends to be somewhat ...

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