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  • Genome 3D-architecture: Its plasticity in relation to function 
    SENGUPTA, KUNDAN (Springer Nature, 2018-04)
    The genome of higher eukaryotes is non-randomly organized in the interphase nucleus. However, notwithstanding the absence of membrane bound sub-compartments, the nucleus coordinates a number of functions largely by organizing ...
  • A Novel cis Regulatory Element Regulates Human XIST in a CTCF-Dependent Manner 
    SHAH, RINI; SHARMA, ANKITA; KELKAR, ASHWIN; SENGUPTA, KUNDAN; GALANDE, SANJEEV (American Society for Microbiology, 2021-07)
    The long noncoding RNA XIST is the master regulator for the process of X chromosome inactivation (XCI) in mammalian females. Here, we report the existence of a hitherto-uncharacterized cis regulatory element (cRE) within ...
  • A universal framework for detecting cis-regulatory diversity in DNA regions 
    BISWAS, ANUSHUA; NARLIKAR, LEELAVATI (Cold Spring Harbor Laboratory Press, 2021-09)
    High-throughput sequencing-based assays measure different biochemical activities pertaining to gene regulation, genome-wide. These activities include transcription factor (TF)–DNA binding, enhancer activity, open chromatin, ...
  • Nup93 and CTCF modulate spatiotemporal dynamics and function of the HOXA gene locus during differentiation 
    LABADE, AJAY S.; SALVI, ADWAIT; KAR, SASWATI; KARMODIYA, KRISHANPAL; SENGUPTA, KUNDAN (The Company of Biologists Ltd, 2021-12)
    Nucleoporins regulate nuclear transport and are also involved in DNA damage, repair, cell cycle, chromatin organization and gene expression. Here, we studied the role of nucleoporin Nup93 and the chromatin organizer CTCF ...