VAP-B is an integral membrane protein, located in the endoplasmic reticulum. In humans, a P56S mutation is associated with familial forms of motor neuron disease. One effect of the mutation is the aggregation of the protein, ...
Amyotrophic Lateral Sclerosis (ALS) is a fatal, motor neurodegenerative disease affecting thousands of people every year worldwide. ~50% of the ALS cases patients display behavioural changes, cognitive and executive ...