Abstract:
C–H functionalization represents a transformative strategy in organic synthesis,
enabling the direct modification of carbon–hydrogen bonds into a wide range of functional
groups. This approach eliminates the need for pre-activated substrates, thereby enhancing step
economy, reducing waste, and improving overall synthetic efficiency. Its ability to achieve site-
selective transformations has opened new avenues for the streamlined construction of
structurally diverse and complex molecules. The present dissertation explores the strategic
development of novel C–H functionalization methodologies for diverse organic scaffolds
including cyclic 1,3-diketones, quinoxalinones, and α-aryl esters. Direct C–H bond
transformation remains a powerful approach in organic synthesis, enabling atom- and step-
economical access to complex molecules. This work emphasizes metal-free and photocatalytic
protocols under mild conditions, aligning with the principles of green and sustainable
chemistry. Cyclic 1,3-diketones, owing to their enolizable nature, serve as versatile
nucleophilic partners for constructing functionalized heterocycles. Quinoxalinones, as
privileged nitrogen heterocycles, were further modified via selective C–H functionalization to
expand their chemical and biological utility and the same methodology has been applied to α-
diazo esters. In parallel, α-aryl esters were investigated for site-selective functionalization,
unlocking pathways for the formation of new C–N and C–C bonds.
